Ụlọ ọrụ kemịkalụ dị mma bụ mpaghara akụ na ụba nke imepụta kemịkalụ dị mma na ụlọ ọrụ kemịkalụ, nke dị iche na ngwaahịa kemịkalụ izugbe ma ọ bụ kemịkalụ dị ukwuu. Ya isi e ji mara bụ na-emepụta elu-edu, multi-iche iche, pụrụ iche ma ọ bụ multi-arụ ọrụ ezi kemịkal maka ụwa aku na uba na ndị mmadụ ndụ na elu na ọhụrụ technology.Fine chemical ụlọ ọrụ nwere elu technology njupụta na elu kwukwara value.Since 1970s, ụfọdụ mba mepere emepe nke ọma gbanwere atụmatụ atụmatụ nke mmepe ụlọ ọrụ kemịkalụ na ụlọ ọrụ kemịkalụ dị mma, na ime ka mmepe nke ụlọ ọrụ kemịkalụ dị mma aghọwo ihe a na-ewu ewu n'ụwa niile. Chemicals dị mma gụnyere ọgwụ pesticides, ọgwụ, agba (pigmenti), wdg. nri mgbakwunye, nri mgbakwunye, adhesives, surfactants, mmiri ọgwụgwọ chemicals, akpụkpọ anụ, oilfield chemicals, electronic chemicals, papermakers and other more than 50 fields.

Pharmaceutical intermediates na-ezo aka n'etiti chemicals mere na usoro nke chemical ọgwụ synthesis na bụ nke ezi chemical ngwaahịa. Pharmaceutical intermediates nwere ike kewaa n'ime ọgwụ nje intermediates, antipyretic na analgesic intermediates, obi obi intermediates, na anticancer intermediates dị ka ha ngwa ubi.The upstream ụlọ ọrụ. nke pharmaceutical intermediates bụ isi chemical akụrụngwa ụlọ ọrụ, mgbe downstream ụlọ ọrụ bụ chemical API na nkwadebe Industry. Dị ka a nnukwu commodity, price nke isi chemical akụrụngwa fluctuates ukwuu, nke ozugbo emetụta mmepụta na-eri nke Enterprises.Pharmaceutical intermediates na ekewa n'ime isi etiti na elu etiti, isi etiti n'ihi mmepụta nkà na ụzụ isi ike adịghị elu, ọnụ ahịa dị ala, na agbakwunyere uru na ọnọdụ oversupply, elu intermediates bụ isi etiti mmeghachi omume ngwaahịa, jiri ya tụnyere nke mbụ etiti, mgbagwoju Ọdịdị, dị nnọọ. otu ma ọ bụ nzọụkwụ ole na ole iji kwadebe ngwaahịa dị elu na-agbakwunye na ala ala, ọnụ ọgụgụ ya dị elu dị elu karịa ụlọ ọrụ etiti ụlọ ọrụ dị elu. Dị ka ndị na-emepụta ihe na-emepụta ihe bụ isi nwere ike inye nanị mmepụta ihe dị n'etiti, ha nọ n'ihu njedebe nke ụlọ ọrụ mmepụta ihe. yinye na nrụgide asọmpi kachasị ukwuu na nrụgide ọnụahịa, na mgbanwe ọnụahịa nke ihe ndị bụ isi kemịkalụ nwere mmetụta dị ukwuu na ha. Senior intermediate suppliers, n'aka nke ọzọ, ọ bụghị nanị nwere ike azụmahịa ike n'elu junior suppliers, ma ihe ka mkpa, ha. na-ebu mmepụta nke etiti etiti dị elu na ọdịnaya teknụzụ dị elu ma na-enwe mmekọrịta chiri anya na ụlọ ọrụ mba dị iche iche, yabụ mgbanwe ọnụahịa nke akụrụngwa na-enwe obere mmetụta na ha. Ndị na-abụghị gmp intermediates na GMP intermediates nwere ike nkewa dị ka ogo nke mmetụta na ikpeazụ. API quality.Non-gmp intermediate na-ezo aka n'etiti ọgwụ tupu API amalite ihe;GMP etiti na-ezo aka na-emepụta ọgwụ na-emepụta n'okpuru ihe achọrọ nke GMP, ya bụ, ihe a na-emepụta mgbe API malite ihe, n'oge nhazi API. nzọụkwụ, na nke ahụ na-aga n'ihu mgbanwe ma ọ bụ nchacha mkpụrụ ndụ tupu aghọọ API.

Ọnụ ọnụ ọnụ ugwu patent nke abụọ ga-aga n'ihu na-akpalite ọchịchọ nke etiti etiti
The pharmaceutical intermediate ụlọ ọrụ fluctuates n'okpuru mmetụta nke mkpokọta ina nke downstream ọgwụ ụlọ ọrụ, na ya periodicity bụ ihu ọma kwekọrọ na nke na-emepụta ọgwụ ụlọ ọrụ.These mmetụta nwere ike kewara n'ime mpụga ihe na esịtidem ihe: mpụga ihe tumadi na-ezo aka na ihu ọma. okirikiri nke ọhụrụ ọgwụ na ahịa;Internal ihe tumadi na-ezo aka patent nchebe okirikiri nke ọhụrụ ọgwụ.The ijeụkwụ nke ọhụrụ ọgwụ nkwado site ọgwụ na-achịkwa ụlọ ọrụ dị ka FDA nwekwara a ụfọdụ mmetụta na ụlọ ọrụ. Mgbe ogologo oge nke nkwado ọgwụ ọhụrụ na ọnụ ọgụgụ nke ọgwụ ọhụrụ akwadoro dị mma maka ụlọ ọrụ ọgwụ, a ga-emepụta ọchịchọ maka ọrụ mgbasa ozi ọgwụ. Dabere na ọnụ ọgụgụ nke ọgwụ ọhụrụ kemịkal na ọgwụ ọhụrụ ndị dị ndụ nke FDA kwadoro na afọ iri gara aga, ọnụ ọgụgụ dị ukwuu nke nkwenye ọgwụ ọhụrụ ga-anọgide na-emepụta ọchịchọ maka ndị na-ahụ maka etiti dị elu, si otú a na-akwado ụlọ ọrụ ahụ iji nọgide na-enwe ọganihu dị elu. Ozugbo nchebe patent nke ọgwụ ọhụrụ na-agwụ, a ga-emeziwanye ọgwụ ndị na-emepụta ihe na-eme ka ọ dịkwuo mma, na ndị na-emepụta ihe na-emepụta ihe ga-adịwanye mma. ka na-anụ ụtọ uto mgbawa nke ọchịchọ na obere oge. Dị ka ọnụ ọgụgụ Evaluate si kwuo, a na-eme atụmatụ na site na 2017 ruo 2022, a ga-enwe ijeri yuan 194 nke ahịa ọgwụ na-eche ọnọdụ nke njedebe patent ihu, nke bụ ọnụ ọgụgụ kasị elu nke abụọ patent kemgbe 2012.

Ariations na afọ ndị na-adịbeghị anya, na mgbasawanye na usoro ọgwụ mgbagwoju anya, nchọpụta ọgwụ ọhụrụ na ọganihu ọganihu mmepe na-ebelata, mmụba ngwa ngwa nke nchọpụta ọgwụ ọhụrụ na mmepe mmepe nke McKinsey na Nat. Rev. DrugDiscov. "kwuru, na 2006-2011, ọhụrụ ọgwụ nnyocha na mmepe ọganihu ọnụego bụ nanị 7.5%, si 2012 ka 2014, n'ihi na ndu macromolecules ezi selectivity na ala toxicity nke miss anya (ọgwụ na mbubreyo mmepe ogbo, ya bụ, si na-adakarị na-adọ III ka mma ndepụta nwere 74% ịga nke ọma ọnụego), ọgwụ nnyocha na mmepe mkpokọta ịga nke ọma ọnụego nke abawanye ubé, ma ka siri ike ndabere ruo 16.40% ihe ịga nke ọma ọnụego na 90 s. Ọnụ nke ọma depụta ọhụrụ. ọgwụ abawanyela site na anyị ijeri $1.188 na 2010 nye anyị ijeri $2.18 na 2018, ihe fọrọ nke nta ka ọ bụrụ okpukpu abụọ. Ka ọ dị ugbu a, nlọghachi nke ọgwụ ọhụrụ na-aga n'ihu na-agbada. Na 2018, ndị dike ụwa TOP12 na-ahụ maka ọgwụ na-eme naanị 1.9% na ntinye ego na nyocha na mmepe.

Ọnụ ego r & d na-abawanye na ịla azụ na ntinye ego r & d ewetala nnukwu nrụgide nye ụlọ ọrụ ọgwụ, n'ihi ya, ha ga-ahọrọ ịnyefe usoro mmepụta na ụlọ ọrụ CMO n'ọdịnihu iji belata ụgwọ. Dị ka ChemicalWeekly si kwuo, usoro mmepụta ihe na-eme ihe dị ka 30% nke ngụkọta ego nke ọgwụ mbụ ahụ. Ụdị CMO / CDMO nwere ike inyere ndị ụlọ ọrụ ọgwụ aka ibelata ọnụ ahịa nke ntinye ego a kapịrị ọnụ, mmepụta mmepụta ihe, ọrụ mmadụ, asambodo, nyocha na akụkụ ndị ọzọ. site 12-15% .Na mgbakwunye, na ADOPTION nke CMO / CDMO mode nwere ike inyere ụlọ ọrụ ọgwụ aka melite mmeghachi omume mkpụrụ, ebelata stocking okirikiri ma dịkwuo nchekwa ihe, nke nwere ike ịzọpụta oge nke mmepụta customization, ebelata r & d okirikiri nke ọgwụ ọhụrụ, na-eme ka ahịa ahịa ọgwụ dị ngwa ngwa, ma mee ka ụlọ ọrụ na-emepụta ọgwụ nwee ike ịnweta oke patent ọzọ.

Ụlọ ọrụ ndị China CMO nwere uru dị ka ọnụ ala dị ala nke akụrụngwa na ọrụ, usoro mgbanwe na nkà na ụzụ, wdg, na ịnyefe ụlọ ọrụ CMO mba ụwa na China na-akwalite mgbasawanye nke ahịa CMO nke China. A na-atụ anya ahịa CMO / CDMO zuru ụwa ọnụ. gafere anyị ijeri $102.5 na 2021, yana ọnụ ọgụgụ uto nke ihe dị ka 12.73% na 2017-2021, dịka amụma South si kwuo.

Na zuru ụwa ọnụ mma chemical ahịa na 2014, pharmaceutical na ya intermediates, pesticide na intermediates bụ n'elu abụọ sub-ụlọ ọrụ nke ezi chemical ụlọ ọrụ, aza 69% na 10% karị.China nwere ike petrochemical ụlọ ọrụ na a ọnụ ọgụgụ buru ibu nke. chemical raw material emepụta, nke kpụrụ ulo oru ụyọkọ, na-eme ka ọtụtụ ụdị nke raw na inyeaka ihe dị mkpa maka mmepụta nke elu-ọkwa ezi kemịkalụ dị na China, na-emeziwanye arụmọrụ na mbenata mkpokọta cost.N'otu oge ahụ, China nwere a dịtụ ala. usoro mmepụta ihe zuru oke, nke na-eme ka ọnụ ahịa akụrụngwa, ihe owuwu na ntinye na China dị ala karịa nke mba ndị mepere emepe ma ọ bụ ọbụna mba ndị ka na-emepe emepe, si otú a na-ebelata ego ntinye ego na mmepụta ihe. Tụkwasị na nke ahụ, China nwere ọnụ ọgụgụ buru ibu nke nwere ike na obere- na-eri chemical engineers na ụlọ ọrụ mmepụta ihe.Intermediates ụlọ ọrụ na China ka mepụtara site na nkà mmụta sayensị nnyocha na mmepe na mmepụta na ahịa nke a zuru ezu set nke dịtụ zuru ezu usoro, ọgwụ mmepụta nke chemical akụrụngwa na intermediates maka isi nwere ike na-etolite a zuru ezu set, nanị ole na ole. mkpa mbubata, nwere ike na-emepụta ọgwụ intermediates, pesticide intermediates na ndị ọzọ 36 isi edemede, ihe karịrị 40000 iche iche nke intermediates, e nwere ọtụtụ n'etiti ngwaahịa enweta a nnukwu ọnụ ọgụgụ nke mbupụ, etiti mbupụ nke ihe karịrị 5 nde tọn kwa afọ, aghọwo ụwa. nnukwu intermediates mmepụta na mbupụ.

China si pharmaceutical intermediates ụlọ ọrụ e nke ukwuu mepụtara kemgbe 2000. N'oge ahụ, ọgwụ ụlọ ọrụ na mba ndị mepere emepe na-akwụ ụgwọ ka ukwuu na-elebara ngwaahịa nnyocha na mmepe na ahịa mmepe dị ka isi asọmpi ha na accelerated nyefe nke intermediates na-arụsi ọrụ ike ọgwụ njikọ na mba ndị ka na-emepe emepe. na ọnụ ala dị ala.Ya mere, ụlọ ọrụ ndị na-emepụta ọgwụ na China na-eji ohere a nweta ọganihu magburu onwe ya. Mgbe ihe karịrị afọ iri nke ọganihu na-aga n'ihu, China aghọwo ihe dị mkpa na-emepụta ihe na-emepụta ihe na-arụ ọrụ n'ụwa nile na ụlọ ọrụ ọgwụ na nkwado nke mba n'ozuzu iwu na dị iche iche atumatu.Site na 2012 na 2018, mmepụta nke China na-emepụta ọgwụ intermediates ụlọ ọrụ mụbara site banyere 8.1 nde tọn na a ahịa size nke banyere 168.8 ijeri yuan ka banyere 10.12 nde tọn na a ahịa size nke 2017 ijeri yuan. China si pharmaceuticals. ụlọ ọrụ intermediates enwetawo asọmpi siri ike n'ahịa, na ọbụna ụfọdụ ndị na-emepụta ihe na-emepụta ihe enwewo ike ịmepụta ndị na-eme ihe n'etiti na mgbagwoju anya molecular Ọdịdị na elu oru chọrọ. Ọnụ ọgụgụ dị ukwuu nke ngwaahịa ndị nwere mmetụta amalitela ịchịkwa ahịa mba ụwa. Otú ọ dị, n'ozuzu ya, ụlọ ọrụ etiti China ka na-emepụta oge mmepe nke njikarịcha na nkwalite ngwaahịa, na ọkwa nkà na ụzụ ka dị ala. Ọtụtụ n'ime ngwaahịa ndị dị na ya. ụlọ ọrụ ndị na-ahụ maka ọgwụ na-emepụta ọgwụ ka bụ ndị na-emepụta ọgwụ ndị bụ isi, ebe ọnụ ọgụgụ dị ukwuu nke ndị na-ahụ maka ọgwụ na-akwado ndị na-akwado ọgwụ ọhụrụ akwadoro dị ụkọ.